The cast of "Monsters vs. Aliens" includes: Oscar® winner Reese Witherspoon ("Walk the Line," "Rendition") as Susan Murphy, a.k.a. Ginormica; Golden Globe winner Hugh Laurie (TV's "House," "Stuart Little") as Dr. Cockroach, Ph.D.; Will Arnett (TV's "Arrested Development," "Blades of Glory") as The Missing Link; Seth Rogen ("Knocked Up," "Superbad") as B.O.B.; Rainn Wilson ("Juno," TV's "The Office") as Gallaxhar; Emmy winner Stephen Colbert (TV's "The Colbert Report," "Bewitched") as The President of the United States; Golden Globe winner Kiefer Sutherland (TV's "24," "Phone Booth") as General W.R. Monger; and Paul Rudd ("Knocked Up," "Night at the Museum") as Susan's boyfriend, Derek.

"Monsters vs. Aliens" is directed by Rob Letterman ("Shark Tale") and Conrad Vernon ("Shrek 2"), produced by Lisa Stewart ("I Think I Love My Wife") and co-produced by Jill Hopper and Latifa Ouaou. The film marks the theatrical debut of DreamWorks Animation's Ultimate 3-D, the studio's proprietary production process of authoring its animated films in 3-D from start to finish.